Morphometric and morphologic evaluation of pulmonary lesions in beagle dogs chronically exposed to high ambient levels of air pollutants.

@article{Hyde1978MorphometricAM,
  title={Morphometric and morphologic evaluation of pulmonary lesions in beagle dogs chronically exposed to high ambient levels of air pollutants.},
  author={Dallas W. Hyde and John G. Orthoefer and Donald L. Dungworth and William Tyler and Reginald C Carter and Henry Lum},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1978},
  volume={38 4},
  pages={
          455-69
        }
}
Beagle dogs (104) comprising one control and seven treatment groups were exposed 16 hours daily for 68 months to filtered air, raw or photochemically reacted auto exhaust, oxides of sulfur or nitrogen, or their combinations. After a further 32 to 36 months in clean air, morphologic examination of lungs by light microscopy, scanning electron microscopy, and transmission electron microscopy revealed two important exposure-related lesions. They were enlargement of air spaces in proximal acinar… CONTINUE READING

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