Morphometric and Biomechanical Intestinal Remodeling Induced by Fasting in Rats

  title={Morphometric and Biomechanical Intestinal Remodeling Induced by Fasting in Rats},
  author={Yanling Dou and S{\o}ren Gregersen and Jingbo Zhao and Feng-yuan Zhuang and Hans Gregersen},
  journal={Digestive Diseases and Sciences},
The function of the small intestine is mechanical to a large degree. To understand the function it is necessary to know how the mechanical stresses and strains can be computed. Nutrition plays an important role in the maintenance of normal gut structure and function. The small intestine undergoes functional changes when food is withheld. To explore the morphological and biomechanical remodeling during starvation, intestinal segments from the fed and fasted rat duodenum, jejunum, and ileum were… 
Small intestinal morphometric and biomechanical changes during physiological growth in rats.
Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats
It was found that the circumferential and longitudinal stiffness of the intestinal wall increased with the duration of diabetes, and morphological and biomechanical remodelling of the small intestine occurred during the development of diabetes.
Intestinal Mechanomorphological Remodeling Induced by Long-Term Low-Fiber Diet in Rabbits
Long-term low-fiber diet in rabbits induced histomorphometric and biomechanical remodelling of the intestines and the wall stiffness was associated with wall thickness and collagen fraction in the submucosa layer.
Biomechanical Remodeling of the Chronically Obstructed Guinea Pig Small Intestine
The morphologic and biomechanical remodeling likely influence the function of the intestine affected by partial obstructed intestine and strong correlation was found between the collagen content and the elastic modulus at stress levels of 70 kPa stress and 10 k Pa stress suggesting that the alteration of collagen has great impact on the mechanical remodeling.
Intestinal remodelling in mink fed with reduced protein content.
Biomechanical remodelling of obstructed guinea pig jejunum.
Biomechanical properties of ileum after systemic treatment with epithelial growth factor.
EGF can cause significant changes both in the morphology and in the passive mechanical properties of the rat ileum, as well as the effect of this growth process on morphometric and biomechanical parameters of ilesum.
Effect of tangweian jianji on upper gastrointestinal remodeling in streptozotocin-induced diabetic rats.
The blood glucose level was significantly higher and the serum insulinlevel was significantly lower in DM, T1 and T2 groups than in the control group, and the wet weight per unit length, wall thickness and opening angle of esophageal and intestinal segments in the DM group were significantly higher than those in the Control group.


The effect of fasting on disaccharidase activity in the rat small intestine.
It is postulate that the activity of the "acid" β-galactosidase located in the cytoplasm or lysosomes of the epithelial cells was stimulated by fasting, and decreased total intestinal sucrase and maltase activities to a loss of total epithelial cell mass in the small bowel.
Elastic properties in the circumferential direction in isolated rat small intestine.
The aim was to study the passive biomechanical wall properties in the isolated duodenum, jejunum and ileum of the rat. The organ bath contained a Krebs-Ringer solution with 10(-2) M MgCl2 to abolish
Passive elastic wall properties in isolated guinea pig small intestine
Differences in elastic properties were found between the proximal and distal small intestine.
Effects of fasting and refeeding on structures of the intestinal villi and epithelial cells in White Leghorn hens.
The results lead to the conclusion that long-term for force moulting is possible, that a high protein and high energy diet can be fed immediately after fasting and that a cell undergoing lysosomal autophagy in normal chickens indicates undernutrition.
Mechanical Properties and Collagen Content Differ Between Isolated Guinea Pig Duodenum, Jejunum, and Distal Ileum
An association was found between the collagen content and the incremental elastic modulus (stiffness) at a stress level of 70 kPa (P <0.05) and the steady-state values of wall thickness, internal radius, and applied pressure.
Biomechanics of the gastrointestinal tract
  • H. Gregersen, G. Kassab
  • Biology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 1996
The physiological and clinical importance of acquiring biomechanical data, distensibility parameters and interpretation of these results and their associated errors are discussed and several techniques to study the mechanical properties of the GI tract are outlined.
Influence of nutrient delivery on gut structure and function.
Although enteral delivery of nutrients is the preferred route for maintenance of intestinal mass, provision of specific nutrients and hormonal stimulation during parenteral alimentation has been shown to be important in maintaining mucosal structure and function.
Differences exist in passive elastic wall properties between segments of isolated guinea‐pig distal ileum and duodenum in vitro
Bomechanical differences were found between the proximal and distal small intestine and these properties may be related to the specialized functions of the two segments, e.g. flow properties.
On the musculature of the gastro-intestinal tract of the guinea-pig
The functional significance of the taeniae is discussed in terms of an arrangement allowing reduction of the lumen of the organ more efficiently than if the longitudinal musculature were spread over the entire surface of theorgan.
Effects of nutrients, endogenous secretions, and fasting on in vitro glucose uptake.
The results indicate that luminal nutrients maintain carrier-mediated glucose transport after direct contact with the mucosa, and the nutrient effect appears to involve an increased number of glucose carriers per cell without a change in carrier affinity for glucose.