Morphometric analysis of alveolar responses of F344 rats to subchronic inhalation of nitric oxide.

  title={Morphometric analysis of alveolar responses of F344 rats to subchronic inhalation of nitric oxide.},
  author={Robert R. Mercer},
  journal={Research report},
  pages={1-15; discussion 17-9}
Nitric oxide (NO)*, the principal airborne pollutant generated from combustion processes such as gas stoves, tobacco smoke, and burning of fossil fuels, is being tested as a therapeutic agent in clinical trials. A prior morphometric study of rats exposed for 9 weeks to 0.5 parts per million (ppm) NO demonstrated focal degeneration of the alveolar interstitium and increased numbers of fenestrated alveolar septa (Mercer et al. 1995). The limited size and distribution of defects in this NO… CONTINUE READING
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