Morphometric analysis of Huntington's disease neurodegeneration in Drosophila.

  title={Morphometric analysis of Huntington's disease neurodegeneration in Drosophila.},
  author={Wan Young Song and Marianne R Smith and Adeela Syed and Tam{\'a}s Luk{\'a}csovich and Brett A Barbaro and Judith M Purcell and Doug J Bornemann and John Burke and J. Lawrence Marsh},
  journal={Methods in molecular biology},
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The HD gene encodes the huntingtin protein (HTT) that contains polyglutamine tracts of variable length. Expansions of the CAG repeat near the amino terminus to encode 40 or more glutamines (polyQ) lead to disease. At least eight other expanded polyQ diseases have been described. HD can be faithfully modeled in Drosophila with the key features of the disease such as late onset, slowly progressing degeneration… CONTINUE READING