Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.
@article{Ramrattan1994MorphometricAO, title={Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.}, author={R. S. Ramrattan and T. L. van der Schaft and C. Mooy and W. D. de Bruijn and P. Mulder and P. T. D. de Jong}, journal={Investigative ophthalmology & visual science}, year={1994}, volume={35 6}, pages={ 2857-64 } }
PURPOSE
To quantify changes in choriocapillary density and in thickness of Bruch's membrane, the choriocapillaris, and the choroid in 95 unpaired, histologically normal human maculae aged 6 to 100 years and in 25 maculae with advanced age-related macular degeneration.
METHODS
Light microscopic, computer-aided, morphometric quantitative analysis.
RESULTS
In ten decades, Bruch's membrane thickness increased by 135%, from 2.0 to 4.7 microns; the choriocapillary density decreased by 45%; the… CONTINUE READING
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References
SHOWING 1-10 OF 31 REFERENCES
Histologic features of the early stages of age-related macular degeneration. A statistical analysis.
- Medicine, Computer Science
- Ophthalmology
- 1992
- 170
Is basal laminar deposit unique for age-related macular degeneration?
- Medicine, Computer Science
- Archives of ophthalmology
- 1991
- 63
Does the retinal pigment epithelium polarize the choriocapillaris?
- Chemistry, Medicine
- Investigative ophthalmology & visual science
- 1986
- 49
Ageing and degeneration in the macular region: a clinico-pathological study.
- Medicine
- The British journal of ophthalmology
- 1976
- 730
- PDF
RPE destruction causes choriocapillary atrophy.
- Chemistry, Medicine
- Investigative ophthalmology & visual science
- 1984
- 356
- PDF