Morphology of hepatitis C and hepatitis B virus particles as detected by immunogold electron microscopy

  title={Morphology of hepatitis C and hepatitis B virus particles as detected by immunogold electron microscopy},
  author={Masahiko Kaito and Satoshi Ishida and Hideaki Tanaka and Shinichiro Horiike and Naoki Fujita and Yukihiko Adachi and Michinori Kohara and Masayoshi Konishi and Shozo Watanabe},
  journal={Medical Molecular Morphology},
We performed indirect immunogold electron microscopy (EM) for immunological identification and characterization of hepatitis C virus (HCV). To clarify the morphology of HCV, an indirect immunogold EM of two plasma samples from patients with high HCV RNA titers was carried out using antibodies specific for the putative HCV envelope protein (E) 1. Spherical virus particles 55–65 nm in diameter with delicate spike projections were detected in the 1.14–1.16 g/ml fractions after sucrose density… 
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  • M. Medici, G. Furlini, C. Chezzi
  • Medicine, Biology
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2011
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Hepatitis C virus core particle detected by immunoelectron microscopy and optical rotation technique.
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To clarify the morphology of hepatitis C virus (HCV), an indirect immunogold electron microscopic study was carried out on two plasma samples with high HCV RNA titres using polyclonal and monoclonal
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