Morphology of CaCo-2 cells varies in different cell batches

  title={Morphology of CaCo-2 cells varies in different cell batches},
  author={Gerhard Herold and Gerhard Rogler and Daniela Rogler and Eduard F Stange},
  journal={In Vitro Cellular & Developmental Biology - Animal},
Dear Editor: The cell line CaCo-2, originally establisbed in 1977 by Fogh el at. (5), is capable of enterocytic differentiation (4,9). Differentiated CaCo-2 cells develop high levels of lactase, sucrase-isomahase, and alkaline phosphatase, and are regarded as a valid model system, Simultaneously, typical brush border membranes characterize the morphologic differentiation (9) and tight junctions indicate a polarization of the cells (9). The results of previous work led to a confusing discussion… CONTINUE READING

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