Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus.


Substance P (SP) is known to be a peptide that facilitates epileptic activity of principal cells in the hippocampus. Paradoxically, in other models, it was found to be protective against seizures by activating substance P receptor (SPR)-expressing interneurons. Thus, these cells appear to play an important role in the generation and regulation of epileptic… (More)