Morphology and secretory activity of digitonin- and alpha-toxin-permeabilized chromaffin cells.

@article{Grant1987MorphologyAS,
  title={Morphology and secretory activity of digitonin- and alpha-toxin-permeabilized chromaffin cells.},
  author={Nancy J. Grant and Dominique Aunis and M. F. Bader},
  journal={Neuroscience},
  year={1987},
  volume={23 3},
  pages={
          1143-55
        }
}
An ultrastructural examination of cultured bovine chromaffin cells permeabilized with Staphylococcus aureus alpha-toxin or digitonin revealed differences in the preservation of cell morphology. The toxin-treated cells closely resembled control cultured cells whereas digitonin-treated cells showed gradations in cytoplasmic densities suggesting extraction, some swelling of the endoplasmic reticulum and, occasionally, discontinuities in the plasma membrane and free granules in the extracellular… CONTINUE READING