Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices.

@article{Lupp2001MorphologyAC,
  title={Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices.},
  author={Amelie Lupp and Manfred Danz and Dieter Mueller},
  journal={Toxicology},
  year={2001},
  volume={161 1-2},
  pages={53-66}
}
Precision-cut liver slices are a widely accepted in vitro system for the examination of drug metabolism, enzyme induction, or hepatotoxic effects of xenobiotics. The maintenance of the distinct lobular expression and induction pattern of phase I biotransformation enzymes, however, has not been examined systematically so far. Thus, in the present study, both longitudinal and transversal sections of male rat liver slices were investigated morphologically, as well as immunohistochemically for the… CONTINUE READING

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