Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(ɛ-caprolactone)/polystyrene blends.

@article{Motealleh2014MorphologyDR,
  title={Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(ɛ-caprolactone)/polystyrene blends.},
  author={Behrooz Motealleh and Payam Zahedi and Iraj Rezaeian and Morvarid Moghimi and Amir H Abdolghaffari and Mohammad Amin Zarandi},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2014},
  volume={102 5},
  pages={977-87}
}
For the first time, it has been tried to achieve optimum conditions for electrospun poly(ε-caprolactone)/polystyrene (PCL/PS) nanofibrous samples as active wound dressings containing chamomile via D-optimal design approach. In this work, systematic in vitro and in vivo studies were carried out by drug release rate, antibacterial and antifungal evaluations, cell culture, and rat wound model along with histology observation. The optimized samples were prepared under the following electrospinning… CONTINUE READING
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