Morphological studies on the pathogenesis of Reinke's edema

  title={Morphological studies on the pathogenesis of Reinke's edema},
  author={Bernhard N. Tillmann and Heinrich H. Rudert and Michael Sch{\"u}nke and Jochen Alfred Werner},
  journal={European Archives of Oto-Rhino-Laryngology},
Light microscopy of vocal cord mucosa in patients with Reinke's edema revealed highly ramified fissured spaces in the subepithelial tissue that were generally lined with flat cells. The ultrastructure of the parietal cells resembled fibroblasts whose cytoplasmic extensions overlapped in two to three layers in some places. Cell contacts were not observed. Neither electron microscopy nor immunohistochemical testing with antibody against laminin demonstrated a basal membrane. It was possible to… 

Inflammatory cell types in Reinke's edema

In Reinke's edema the main pathologic finding is the collection of edematous fluid in Reince's space, and no statistically significant correlation between the inflammatory cell types and clinical characteristics of Reinke’s edema was found.

[Rigid telescopy and contact endoscopy in the diagnosis and surgery of Reinke's oedema--clinical and histological assessment].

For the first time during the laryngological praxis, a number of parameters that appeared to be significant in the monitoring and detailed evaluation of Reinke's oedema were discussed, particularly when access to the larynx is difficult.

Proteomic Analysis of Vocal Fold Fibroblasts Exposed to Cigarette Smoke Extract: Exploring the Pathophysiology of Reinke's Edema.

It is postulate that changes in the composition of the vocal folds' extracellular matrix -reduction of collagen fibrils, increase of hyaluronan- may lead to the clinical findings, which might ease the identification of better, disease-specific treatment options.

Reinke's Edema.

Proteomic Analysis of Vocal Fold Fibroblasts Exposed to Cigarette Smoke Extract: Exploring the Pathophysiology of Reinke's Edema*

It is postulated that changes in the composition of the vocal folds' extracellular matrix -reduction of collagen fibrils, increase of hyaluronan- may lead to the clinical findings of Reinke's edema, and this might ease the identification of better, disease-specific treatment options.

The Clinical Characteristics and Voice Analysis of Reinke's Edema

The fundamental frequency was approximated to normal ranges, and stabilizing of vocal fold vibration, and the improvement of vocal efficiency was also found 2 months after layngomicrosurgery.

Hyaluronic Acid Concentration in Female Vocal Folds With Reinke’s Edema

Vocal fold covers affected by Reinke’s edema present a higher concentration of HA than do vocal fold covers with no edema, and this concentration was significantly higher than that in the control vocal folds.

Structure of caveolae.

  • R. Stan
  • Biology
    Biochimica et biophysica acta
  • 2005

CD34‐positive fibroblasts in Reinke's edema

To elucidate whether and to what extent CD34+ fibroblasts occur in normal human vocal folds and in Reinke's edema, a cell-by-cell study is conducted.

Voice analysis of patients with diverse types of Reinke's edema and clinical use of electroglottographic measurements

Comparison of aerodynamic, acoustic and electroglottographic parameters for the different types of Reinke's edema according to its morphological, perceptual and histopathological classifications showed that jitter, the HNR, the mean closed quotient and the irregularity of the frequency were the parameters that had the best correlation with improvement in postoperative voice quality.



[Light and electron microscopy investigations in Reinke's ("polypoid chorditis")].

In nine cases of Reinkes edema ("polypoid chorditis") the resected mucosa is investigated by light and electron microscopy. The characteristic morphological changes of the disease are observed in the

Fine structure of the lysosomes in the two types of synoviocytes of normal rat synovial membrane

The findings that type-A and type-S synoviocytes show distinctly different organization of the lysosomal system indicate that the roles of theLysosomes in these two types of cells may be different.

[Anatomical markers of Reinke's space and the etiopathogenesis of Reinke edema].

The authors suggest that the upper boundary of Reinke's space is functional and that the patient's attempt to compensate the hoarseness by the use of the false vocal cords forces the fluid within Reince's space towards the free edge of the vocal cord.

B-cells of the synovial membrane

The B-cells appear to constitute a category of secretory cells specific to the synovial membrane, but the function of which has yet to be determined.

The morphological basis for development of Reinke's oedema.

Normal human vocal cords and surgically removed Reinke's oedema were studied by light and electron microscopy and suggested the possibility of the lamellae moving on each other, important for the vibratory function of vocal cords.

Monocyte/macrophage-reactive monoclonal antibody Ki-M6 recognizes an intracytoplasmic antigen.

A monoclonal antibody, termed Ki-M6, is described, which shows a restricted reactivity to cells of the monocyte/macrophage system, and binds to a lysosomal membrane-restricted antigen of 60,000 daltons without influencing significantly lysOSome-related functions as far as the chemiluminescence response is concerned.

[Pathogenesis and clinical aspects of Reinke edema. Long-term studies].

Surgical treatment, stripping of the vocal cords as described by Kleinsasser was successful and there were no recurrences and no malignant degenerations, and the prognosis was considered to be good.

Reinke's oedema and thyroid function

The incidence of hypothyroidism in this group of Reinke's oedema patients is higher than expected in a normal population, but it is similar to that in an age and sex matched control group, reflecting the prevalence of Hypo thy roidism in middle aged women.

Laminin--a glycoprotein from basement membranes.

Investigation of a large noncollagenous glycoprotein isolated from a mouse tumor that produces basement membrane shows that it is produced by a variety of cultured cells, suggesting that this protein or an immunologically related protein is a constituent of the basement membranes of these tissues.

Fine Structure of Synovial Joints

For a reviewer to procrastinate over an opinion on any book referred to him is inexcusable, above all in the eyes of the editor. Critics of readable novels should seldom be daunted. By contrast when