Morphological response and survival of hepatoma cells during fractionated hyperthermia: effect of glycerol.

@article{Rijn1984MorphologicalRA,
  title={Morphological response and survival of hepatoma cells during fractionated hyperthermia: effect of glycerol.},
  author={J van Rijn and Jaap van den Berg and Denis H. J. Schamhart and Roeland J van Wijk},
  journal={Radiation research},
  year={1984},
  volume={98 3},
  pages={471-8}
}
Reuber H35 rat hepatoma cells rounded and became spherical during hyperthermia at 42.5 degrees C. When returned to 37 degrees C, the cells recovered and spread out again. As soon as the cells had recovered from the morphologically expressed stress, they expressed tolerance to a second hyperthermia treatment as measured by the same end point. Fractionated hyperthermia made the cells thermotolerant as judged by both the morphological and the cell survival response. Glycerol protected the cells… CONTINUE READING