Morphological observations on the gallbladder of ground squirrels fed a lithogenic diet.

@article{Pemsingh1987MorphologicalOO,
  title={Morphological observations on the gallbladder of ground squirrels fed a lithogenic diet.},
  author={Ramjeet Singh. Pemsingh and B R Macpherson and Grace Workman Scott},
  journal={The Journal of pathology},
  year={1987},
  volume={152 2},
  pages={
          127-35
        }
}
Richardson's ground squirrels (Spermophilus richardsonii) of both sexes were fed a 2 per cent cholesterol-enriched rat chow diet for intervals of 1, 2, 10 and 20 weeks. Light microscopy and 3H-thymidine autoradiography revealed an increase in cell proliferation prior to the occurrence of macroscopically visible stones, but in the presence of crystals and microliths. Transmission electron microscopy studies showed that columnar epithelial cells undergo mitosis rather than basal cells and that… CONTINUE READING