Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice.

@article{HasegawaIshii2011MorphologicalII,
  title={Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice.},
  author={Sanae Hasegawa-Ishii and Shiro Takei and Yoichi Chiba and Ayako Furukawa and Hiroyuki Umegaki and Akihisa Iguchi and Noriko Kawamura and Keisuke Yoshikawa and Masanori Hosokawa and Atsuyoshi Shimada},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2011},
  volume={31 1},
  pages={20-8}
}
The ageing brain is characterized by degenerative changes in both neurons and glia. Although neurons are known to lose dendritic complexity with ageing, age-related changes in the morphology of microglia have not been well documented. We investigated potential age-related changes in microglial morphology using mouse models. Senescence-accelerated mouse prone 10 (SAMP10) in which neuronal degeneration begins to appear around 8 months of age and becomes progressively remarkable with advancing age… CONTINUE READING
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