Morphological evidence for vesicular glutamate release from astrocytes.

Abstract

There is now growing evidence that astrocytes, like neurons, can release transmitters. One transmitter that in a vast number of studies has been shown to be released from astrocytes is glutamate. Although asytrocytic glutamate may be released by several mechanisms, the evidence in favor of exocytosis is most compelling. Astrocytes may respond to neuronal activity by such exocytotic release of glutamate. The astrocyte derived glutamate can in turn activate neuronal glutamate receptors, in particular N-methyl-D-aspartate (NMDA) receptors. Here we review the morphological data supporting that astrocytes possess the machinery for exocytosis of glutamate. We describe the presence of small synaptic-like microvesicles, SNARE proteins and vesicular glutamate transporters in astrocytes, as well as NMDA receptors situated in vicinity of the astrocytic vesicles.

DOI: 10.1016/j.neuroscience.2008.03.074
0100200300200920102011201220132014201520162017
Citations per Year

552 Citations

Semantic Scholar estimates that this publication has 552 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Bergersen2009MorphologicalEF, title={Morphological evidence for vesicular glutamate release from astrocytes.}, author={Linda Hildegard Bergersen and Vidar Gundersen}, journal={Neuroscience}, year={2009}, volume={158 1}, pages={260-5} }