Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.

@article{Kurtz1994MorphologicalEO,
  title={Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.},
  author={Myra Berman Kurtz and Ian Brent Heath and Jean A. Marrinan and Sarah Dreikorn and Junko Onishi and Cameron M. Douglas},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 7},
  pages={
          1480-9
        }
}
The lipopeptide antifungal agents, echinocandins, papulacandins, and pneumocandins, kill Candida albicans by inhibiting glucan synthesis. For this fungus, there is a good correlation of in vitro enzyme inhibition with in vitro assays of MICs. Semisynthetic lipopeptides such as cilofungin, LY303366, L-693,989, and L-733,560 have activity in vivo against Aspergillus infections but appear to be inactive in broth dilution in vitro tests (MICs, > 128 micrograms/ml). To understand how compounds which… CONTINUE READING

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