Morphological effect of lipid carriers on permeation of lidocaine hydrochloride through lipid membranes.

@article{Shim2010MorphologicalEO,
  title={Morphological effect of lipid carriers on permeation of lidocaine hydrochloride through lipid membranes.},
  author={Jongwon Shim and Mi Jin Kim and H N Kim and Do-Hoon Kim and Seong Geun Oh and Seung Yong Ko and Ho Gyeom Jang and Jin-Woong Kim},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={388 1-2},
  pages={251-6}
}
We have studied how the transdermal delivery of lidocaine hydrochloride (LHC) is affected by the morphology of lipid carriers, liposomes and micelles, having the same lipid composition of 1-stearoyl-sn-glycero-3-phosphocholine (LPC) and cholesteryl hemisuccinate (CHEMS). In vitro drug permeation study, carried out on guinea pig skin, has revealed that the liposomes made of LPC and CHEMS significantly enhance the permeation rate of entrapped LHC; by contrast, the mixed micelles with the same… CONTINUE READING

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