Morphological classification of nuchal skin in human fetuses with trisomy 21, 18, and 13 at 12—18 weeks and in a trisomy 16 mouse

@article{Kaisenberg1998MorphologicalCO,
  title={Morphological classification of nuchal skin in human fetuses with trisomy 21, 18, and 13 at 12—18 weeks and in a trisomy 16 mouse},
  author={Constantin S. von Kaisenberg and Veit Krenn and Michael A. Ludwig and Kypros H. Nicolaides and Beate E M Brand-Saberi},
  journal={Anatomy and Embryology},
  year={1998},
  volume={197},
  pages={105-124}
}
 An increase in the nuchal translucency that can be detected at 10–14 weeks of gestation by ultrasound forms the basis for a screening test for chromosomal abnormality. Several mechanisms leading to this increase in skin thickness have been proposed, including changes of the extracellular matrix, cardiac defects and abnormalities of the large vessels. This study examines the composition of the extracellular matrix of the skin in gestational age-matched fetuses with trisomy 21, 18 and 13 from 12… CONTINUE READING

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Collagen VI gene expression in the skin of trisomy 21 fetuses

  • CS VonKaisenberg, B Brand-Saberi, B Christ, S Vallian, S Farzaneh, K Nicolaides
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