Morphological characterization of skeletal cells in Cbfa1-deficient mice.

  title={Morphological characterization of skeletal cells in Cbfa1-deficient mice.},
  author={Kazuto Hoshi and Toshihisa Komori and Hedehiro Ozawa},
  volume={25 6},
To clarify the mechanisms by which core-binding factor-alpha1 (Cbfa1), an essential transcription factor in osteogenesis, functions in osteoblast matrix formation, as well as in chondrocyte differentiation and osteoclastic bone resorption, Cbfa1-deficient embryonic mice were investigated ultrastructurally and histocytochemically at 18.5 days postcoitum. In homozygotic mice, both endochondral and intramembranous ossification were arrested, although bone tissue had already formed at this stage in… CONTINUE READING