Morphological changes in the optic nerve after chronic exposure of neonatal rats to cocaine and amphetamine.

@article{SilvaArajo1991MorphologicalCI,
  title={Morphological changes in the optic nerve after chronic exposure of neonatal rats to cocaine and amphetamine.},
  author={A L Silva-Ara{\'u}jo and Jose Salgado-Borges and Mar{\'i}a Tavares},
  journal={Ophthalmic research},
  year={1991},
  volume={23 6},
  pages={295-302}
}
We determined the effects of cocaine hydrochloride (15 mg/kg body weight/day) or amphetamine sulfate (25 mg/kg body weight/day) on the optic nerve in groups of rats exposed from postnatal day 1 to 30. Qualitative and quantitative studies of cross-sections of the optic nerves showed different patterns of organization, namely the presence of degenerative features in drug-treated animals and significant differences in the proportion of the nerve occupied by glial cells and their processes and… CONTINUE READING