Morphological changes in dendritic spines of Purkinje cells associated with motor learning.

@article{Lee2007MorphologicalCI,
  title={Morphological changes in dendritic spines of Purkinje cells associated with motor learning.},
  author={Kea Joo Lee and Joon Goo Jung and Tatsuo Arii and Keiji Imoto and Im Joo Rhyu},
  journal={Neurobiology of learning and memory},
  year={2007},
  volume={88 4},
  pages={445-50}
}
Experience-dependent changes of spine structure and number may contribute to long-term memory storage. Although several studies demonstrated structural spine plasticity following associative learning, there is limited evidence associating motor learning with alteration of spine morphology. Here, we investigated this issue in the cerebellar Purkinje cells using high voltage electron microscopy (HVEM). Adult rats were trained in an obstacle course, demanding significant motor coordination to… CONTINUE READING