Morphological changes in acute focal ischemia: response to osmotherapy.

  title={Morphological changes in acute focal ischemia: response to osmotherapy.},
  author={J. Russell Little},
  journal={Advances in neurology},
The sequential morphological changes following acute MCA occlusion in conscious cats were studied. The artery was occluded with a simple implanted device that resulted in immediate contralateral hemiparesis. The ischemic changes in the MCA territory developed in a diphasic fashion. Astrocytic swelling and capillary narrowing preceded the development of ischemic neuronal alterations during the primary phase. Capillary obstruction developed during the secondary phase when tissue injury was… CONTINUE READING