Morphological and proliferative responses of endothelial cells to hydrostatic pressure: role of fibroblast growth factor.

@article{Acevedo1993MorphologicalAP,
  title={Morphological and proliferative responses of endothelial cells to hydrostatic pressure: role of fibroblast growth factor.},
  author={A D Acevedo and Samuel S. Bowser and Mary E. Gerritsen and Rena Bizios},
  journal={Journal of cellular physiology},
  year={1993},
  volume={157 3},
  pages={603-14}
}
Subconfluent bovine pulmonary artery endothelial cells on rigid substrates were exposed to 1.5-15 cm H2O sustained hydrostatic pressure for up to 7 days and exhibited elongation, cytoskeletal rearrangement, increased cell proliferation, and bilayering. The role of basic fibroblast growth factor (bFGF) in the mechanism(s) of these endothelial cell responses to sustained hydrostatic pressure was investigated. Evidence that bFGF was released from endothelial cells exposed to sustained hydrostatic… CONTINUE READING
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