Morphological and morphometric studies of the dysmyelinating mutant, the Long Evans shaker rat.

@article{Kwiecien1998MorphologicalAM,
  title={Morphological and morphometric studies of the dysmyelinating mutant, the Long Evans shaker rat.},
  author={Jacek M. Kwiecien and L T O'connor and Brian D. Goetz and Kathleen H Delaney and Andy Fletch and Ian D. Duncan},
  journal={Journal of neurocytology},
  year={1998},
  volume={27 8},
  pages={581-91}
}
The Long Evans shaker (les) rat is a recently identified CNS myelin mutant with an autosomal recessive mode of inheritance. Although scattered myelin sheaths are present in some areas of the CNS, most notably the ventral spinal cord in the young neonatal rat, this myelin is gradually lost, and 8-12 weeks little myelin is present throughout the CNS. Despite this severe myelin deficiency, some mutants may live beyond one year of age. Rare, thin myelin sheaths that are present early in development… CONTINUE READING

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