Morphological and molecular pathology of CCL4-induced hepatic fibrosis in connexin43-deficient mice.

@article{Cogliati2011MorphologicalAM,
  title={Morphological and molecular pathology of CCL4-induced hepatic fibrosis in connexin43-deficient mice.},
  author={Bruno Cogliati and Tereza Cristina da Silva and Thiago Pinheiro Arrais Aloia and Lucas Martins Chaible and Mirela Aline Real-Lima and Daniel Soares Sanches and Patr{\'i}cia Matsuzaki and Francisco Javier Hernandez-Blazquez and Maria L{\'u}cia Zaidan Dagli},
  journal={Microscopy research and technique},
  year={2011},
  volume={74 5},
  pages={421-9}
}
Gap junction channels, formed by connexins (Cx), are involved in the maintenance of tissue homeostasis, cell growth, differentiation, and development. Several studies have shown that Cx43 is involved in the control of wound healing in dermal tissue. However, it remains unknown whether Cx43 plays a role in the control of liver fibrogenesis. Our study investigated the roles of Cx43 heterologous deletion on carbon tetrachloride (CCl(4))-induced hepatic fibrosis in mice. We administered CCl(4) to… CONTINUE READING