Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle.

@article{Vickerton2014MorphologicalAH,
  title={Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle.},
  author={Paula Vickerton and Jonathan C Jarvis and James A. Gallagher and Riaz Akhtar and H. Sutherland and Nathan S Jeffery},
  journal={Proceedings. Biological sciences},
  year={2014},
  volume={281 1788},
  pages={20140786}
}
Muscular contraction plays a pivotal role in the mechanical environment of bone, but controlled muscular contractions are rarely used to study the response of bone to mechanical stimuli. Here, we use implantable stimulators to elicit programmed contractions of the rat tibialis anterior (TA) muscle. Miniature stimulators were implanted in Wistar rats (n = 9) to induce contraction of the left TA every 30 s for 28 days. The right limb was used as a contralateral control. Hindlimbs were imaged… CONTINUE READING

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