Morphological and functional retinal impairment in Alzheimer's disease patients

@article{Parisi2001MorphologicalAF,
  title={Morphological and functional retinal impairment in Alzheimer's disease patients},
  author={Vincenzo Parisi and Rita Restuccia and Francesco Fattapposta and Concetta Mina and Massimo Gilberto Bucci and Francesco Pierelli},
  journal={Clinical Neurophysiology},
  year={2001},
  volume={112},
  pages={1860-1867}
}
OBJECTIVE Our study aims to assess the optic nerve fiber layer thickness in vivo, the function of the innermost retinal layer and whether a correlation exists between morphological and functional parameters in patients affected by Alzheimer's Disease (AD). METHODS Seventeen AD patients (mean age 70.37+/-6.1 years, best corrected visual acuity >8/10 with refractive error between +/-3 sf, intra-ocular pressure (IOP)<18 mmHg) were enrolled. They were compared to 14 age-matched controls. Nerve… Expand
Confocal scanning laser tomography of the optic nerve head on the patients with Alzheimer’s disease compared to glaucoma and control
TLDR
The results suggest that HRT does not demonstrate ONH differences between AD and control group, while it successfully differentiates glaucoma fromAD and control cases of older age. Expand
Measures of Retinal Structure and Function as Biomarkers in Neurology and Psychiatry
TLDR
Retinal findings in psychiatric and neurologic conditions are reviewed in terms of their potential as biomarkers of disease onset, progression, severity, and outcomes and the potential for applications of artificial intelligence to increasing the predictive validity of retinal data is discussed. Expand
Retinal Structural Changes in Patients with Mild Cognitive Impairment
TLDR
The preliminary study results suggest that RNFL overall and temporal thickness in patients with MCI is significantly decreased compared to normal controls and GCC FVL% is significantly increased in patientswith MCI compared tonormal controls suggesting that there is macular focal loss of ganglion cells in MCI patients. Expand
Retinal Nerve Fibre Layer Thinning in Alzheimer Disease
TLDR
Retinal and optic nerve abnormalities have in recent years been studied intensively in Alzheimer disease (AD) and are reviewed in this chapter. Expand
Traumatic optic neuropathy caused by blunt injury to the inferior orbital rim.
TLDR
A 48-year-old woman was struck on the right inferior orbital rim by a gardening device and immediately developed complete visual loss in the right eye, attributing the visual loss to indirect optic nerve injury. Expand
Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
TLDR
The background for AD to accelerate the adoption of retina imaging for the diagnosis and management of AD in clinical practice is outlined and a number of novel approaches in retina imaging have been developed and made it possible to visualize changes in the retina at a very fine resolution. Expand
The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up
TLDR
An analysis of the physiological changes in ocular and cerebral ageing in CNS disorders such as stroke, AD and Parkinson’s disease is performed and the pathophysiology of both the eye and the visual pathway in AD is described. Expand
Meta-analysis of the relationship of peripheral retinal nerve fiber layer thickness to Alzheimer’s disease and mild cognitive impairment
TLDR
Peripheral RNFL thicknesses, particularly in the superior and inferior quadrants, becomes progressively thinner as cognitive function declines, so this could be a candidate biomarker for early identification of AD. Expand
Association of cognitive functioning with retinal nerve fiber layer thickness.
TLDR
Cognitive functioning is associated with RNFL thickness in healthy young individuals and the lack of association in older individuals suggests that loss of neurons in the cerebrum and retina is not concomitant and may have different origins. Expand
Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease
TLDR
Current understanding of retinal structures in AD, mild cognitive impairment (MCI) and preclinical AD is summarized, focusing on neurodegeneration and microvascular changes measured using optical coherence tomography (OCT) and optical coherent tomography angiography (OCTA) technologies. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Optical coherence tomography for imaging and quanti®cation of nerve ®ber layer thickness
  • Schuman JS, editor. Imaging in glaucoma,
  • 1997
Retinal nerve ®ber layer abnormalities in Alzheimer's disease
  • Acta Ophthalmol Scand 1996;74:271±275
  • 1996
Optic-nerve degeneration in Alzheimer's disease.
TLDR
The changes observed in the patients with Alzheimer's disease were clearly distinguishable from the findings in 10 age-matched controls and represent a sensory-system degeneration that occurs in Alzheimer’s disease. Expand
Correlation between morphological and functional retinal impairment in multiple sclerosis patients.
TLDR
There is a correlation between PERG changes and NFL thickness in MS patients previously affected by optic neuritis, but there is no correlation between VEP changes andNFL thickness. Expand
Cytidine-5'-diphosphocholine (citicoline) improves retinal and cortical responses in patients with glaucoma.
TLDR
Citicoline may induce an improvement of the retinal and of the visual pathway function in patients with glaucoma, and the electrophysiologic improvement was still maintained. Expand
Visual function correlates with nerve fiber layer thickness in eyes affected by ocular hypertension.
TLDR
The variability of PERG, VEP, and SCS testing observed in eyes with ocular hypertension is associated with differences in NFL thickness (the thinner the layer, the worse the visual function). Expand
Impaired VEP after photostress response in multiple sclerosis patients previously affected by optic neuritis.
TLDR
The results indicate that patients previously affected by optic neuritis present an abnormal VEP after photostress response and this may be ascribed predominantly to an involvement of the inner retinal layers as indicated by the concomitant impairment of PERG and focal-ERG responses. Expand
Neural conduction in visual pathways in newly-diagnosed IDDM patients.
TLDR
Two sources, one retinal (impaired PERG) and one postretinal (delayed RCT and LW) may independently contribute in to the abnormal responses of VEP observed in newly-diagnosed IDDM patients. Expand
Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients.
TLDR
There is a correlation between PERG changes and NFL thickness, but there is no correlation between VEP changes andNFL thickness in patients affected by OAG. Expand
Impaired visual function in glaucoma
  • V. Parisi
  • Medicine
  • Clinical Neurophysiology
  • 2001
TLDR
In patients with open angle glaucoma the reduction of the index of global visual field damage (MD) could be ascribed to two sources of functional impairment: one retinal (impaired PERG) and one postretinal (delayed RCT and LW). Expand
...
1
2
3
4
5
...