Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction.

@article{DawsonScully2007MorphologicalAF,
  title={Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction.},
  author={Ken Dawson-Scully and Yongqi Lin and M. K. Imad and Jinhui Zhang and Leo Marin and Jane Anne Horne and Ian A. Meinertzhagen and Shanker Karunanithi and Konrad E. Zinsmaier and Harold L. Atwood},
  journal={Synapse},
  year={2007},
  volume={61 1},
  pages={1-16}
}
The synaptic vesicle-associated cysteine string protein (CSP) is critical for neurotransmitter release at the neuromuscular junction (NMJ) of Drosophila, where the approximately 4% of mutant flies lacking CSP that survive to adulthood exhibit spastic jumping and shaking, temperature-sensitive paralysis, and premature death. Previously, it has been shown that CSP is also required for nerve terminal growth and the prevention of neurodegeneration in Drosophila and mice. At larval csp null mutant… CONTINUE READING