Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys.

@article{Gash1995MorphologicalAF,
  title={Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys.},
  author={Don M. Gash and Zhi-Ming Zhang and Wayne A. Cass and Aliza Ovadia and Linda Simmerman and Davy Martin and David R. Russell and Frank Collins and Barry J. Hoffer and Greg A. Gerhardt},
  journal={The Journal of comparative neurology},
  year={1995},
  volume={363 3},
  pages={345-58}
}
Effects of a single injection of either 150 micrograms human recombinant glial cell line-derived neurotrophic factor (rGDNF) or vehicle into the right substantia nigra were analyzed in 12 normal adult female rhesus monkeys. The studies included evaluating whole animal behavior, electrochemical recordings of striatal dopamine release, neurochemical determinations of basal ganglia and nigral monoamine levels, and immunohistochemical staining of the nigrostriatal dopamine system. The behavioral… CONTINUE READING

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