Morphological and functional disturbances of platelets induced by cryopreservation.

  title={Morphological and functional disturbances of platelets induced by cryopreservation.},
  author={H Baythoon and Edward G. D. Tuddenham and Ronald A. Hutton},
  journal={Journal of clinical pathology},
  volume={35 8},
In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activity (PF3a) and a decrease in their aggregability and adenine nucleotide content. We conclude that if transfused, cryopreserved platelets are likely to be less effective than fresh… CONTINUE READING

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