Morphological and functional characterization of an in vitro blood-brain barrier model.

  title={Morphological and functional characterization of an in vitro blood-brain barrier model.},
  author={Kathe A Stanness and Lesnick E. Westrum and Ersilia Fornaciari and Paolo Mascagni and Jay A. Nelson and Stephan Stenglein and Tanya Myers and Damir Janigro},
  journal={Brain research},
  volume={771 2},
Cell culture models have been extensively used for studies of blood-brain barrier (BBB) function. However, several in vitro models fail to reproduce some, if not most, of the physiological and morphological properties of in situ brain microvascular endothelial cells. We have recently developed a dynamic, tridimensional BBB model where endothelial cells exposed to intraluminal flow form a barrier to ions and proteins following prolonged co-culturing with glia. We have further characterized this… CONTINUE READING


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