Morphological and functional characteristics of skeletal muscle fibers from hormone-replaced and nonreplaced postmenopausal women.

@article{Widrick2003MorphologicalAF,
  title={Morphological and functional characteristics of skeletal muscle fibers from hormone-replaced and nonreplaced postmenopausal women.},
  author={Jeffrey J Widrick and Gianni F. Maddalozzo and Danielle K. Lewis and Beth A. Valentine and Dena P. Garner and Julian E. Stelzer and Todd Shoepe and Christine M. Snow},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2003},
  volume={58 1},
  pages={3-10}
}
We tested the hypothesis that cross-bridge mechanisms of contraction differed in early postmenopausal women who did or did not receive hormone replacement therapy (HRT). Vastus lateralis biopsies were obtained from 17 postmenopausal women (49-57 years old), 8 of whom were on HRT for the previous 24 +/- 5 months and 9 of whom were never on HRT. Electrophoresis and enzyme histochemistry revealed that fiber myosin heavy chain (MHC) isoform distribution, the cross-sectional area (CSA) of slow and… CONTINUE READING