Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse

@article{Panayotis2011MorphologicalAF,
  title={Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse},
  author={Nicolas Panayotis and M. Pratte and Ana Borges-Correia and A. Ghata and J. Roux},
  journal={Neurobiology of Disease},
  year={2011},
  volume={41},
  pages={385-397}
}
  • Nicolas Panayotis, M. Pratte, +2 authors J. Roux
  • Published 2011
  • Biology, Medicine
  • Neurobiology of Disease
  • Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the MECP2 gene, in which older patients often develop parkinsonian features. Although Mecp2 has been shown to modulate the catecholaminergic metabolism of the RTT mouse model, little is known about the central dopaminergic neurons. Here we found that the progression of the motor dysfunction in the Mecp2-deficient mouse becomes more severe between 4 and 9 weeks of age. We then studied the phenotype of the dopaminergic… CONTINUE READING
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    References

    SHOWING 1-10 OF 62 REFERENCES
    Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice
    • 38
    Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
    • 137
    • PDF
    Mecp2 Deficiency Disrupts Norepinephrine and Respiratory Systems in Mice
    • 253
    • PDF
    Biogenic Amines in Rett Syndrome: The Usual Suspects
    • 32