Morphological and dynamical properties of semiflexible filaments driven by molecular motors.

@article{Gupta2019MorphologicalAD,
  title={Morphological and dynamical properties of semiflexible filaments driven by molecular motors.},
  author={Nisha R. Gupta and Abhishek Chaudhuri and Debasish Chaudhuri},
  journal={Physical review. E},
  year={2019},
  volume={99 4-1},
  pages={
          042405
        }
}
We consider an explicit model of a semiflexible filament moving in two dimensions on a gliding assay of motor proteins, which attach to and detach from filament segments stochastically, with a detachment rate that depends on the local load experienced. Attached motor proteins move along the filament to one of its ends with a velocity that varies nonlinearly with the motor protein extension. The resultant force on the filament drives it out of equilibrium. The distance from equilibrium is… 
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References

SHOWING 1-10 OF 178 REFERENCES
Active dynamics of filaments in motility assays
Abstract.We study the active dynamics of single and interacting cytoskeletal filaments in motility assays, in which immobilized motor proteins bind the filaments to a surface and actively pull them…
Enhanced ordering of interacting filaments by molecular motors.
TLDR
Langevin dynamics simulations show that the motor activity enhances the tendency for nematic ordering, and a quantitative theory for the location of the phase boundary as a function of motor density is developed.
Autonomous motility of active filaments due to spontaneous flow-symmetry breaking.
TLDR
This work simulates the nonlocal Stokesian hydrodynamics of an elastic filament which is active due a permanent distribution of stresslets along its contour and results can be qualitatively understood as a superposition of translational and rotational motion associated with filament conformational modes of opposite symmetry.
Elastically coupled molecular motors
TLDR
It is found that for a backbone flexibility exceeding a characteristic value, the ability of motors to produce force reduces as compared to rigidly coupled motors, while the maximum velocity remains unchanged.
Forced desorption of semiflexible polymers, adsorbed and driven by molecular motors.
TLDR
A model to describe the dynamics of semiflexible polymers in the presence of activity due to motor proteins attached irreversibly to a substrate, and a transverse pulling force acting on one end of the filament is formed.
Coarse-grained simulations of an active filament propelled by a self-generated solute gradient.
TLDR
This work investigates the dynamics of such an active filament using a bead-spring model with the explicit hydrodynamic interactions and calculates the self-propulsion velocity of the filament for various rigidity and sizes.
Collective dynamics of self-propelled semiflexible filaments.
TLDR
The collective behavior of active semiflexible filaments is studied with a model of tangentially driven self-propelled worm-like chains to encapsulate tunable non-equilibrium steady states that can be used in the organization of living matter.
Flagellar dynamics of a connected chain of active, polar, Brownian particles
TLDR
This study uses a combination of detailed numerical simulations, mean-field scaling analysis and first passage time theory to characterize the phase diagram as a function of the filament length, passive elasticity, propulsion force and noise.
Spontaneous beating and synchronization of extensile active filament.
TLDR
This work simulates a semi-flexible active filament that exhibits spontaneous oscillations on clamping and shows self-propulsion when left free, and demonstrates that the two competing forces necessary for oscillation are the elastic forces due to polymer rigidity and the active forcesDue to chemical activity.
Broken Detailed Balance of Filament Dynamics in Active Networks.
TLDR
This work analytically calculate shape fluctuations of semiflexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity, and investigates how the temporal signatures of motor activity determine mode correlations, which are consistent with recent experiments on microtubules embedded in cytoskeletal networks.
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