Morphological and Functional State of Rat Ovaries in Early and Late Periods after Administration of Platinum Cytostatics

@article{Borovskaya2004MorphologicalAF,
  title={Morphological and Functional State of Rat Ovaries in Early and Late Periods after Administration of Platinum Cytostatics},
  author={Tatyana Gennadyevna Borovskaya and Virginia Goldberg and Tatyana Ivanovna Fomina and Angelina Vladimirovna Pakhomova and Svetlana I Kseneva and Marina Evgenyevna Poluektova and Elkhonen Goldberg},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={137},
  pages={331-335}
}
Experiments on Wistar rats showed that cisplatin and carboplatin induced similar morphological alterations in the ovaries. Both agents reduced the number of structural and functional elements, but the effect of cisplatin was more pronounced. Morphological changes observed in the early period after injection of the preparations were accompanied by prolongation of the estrous cycle, which was longer in rats treated with carboplatin. Partial and reversible sterility was observed in females at the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-3 of 3 references

Introduction [in Russian], St

M. L. Gershanovich, V. A. Filov, M. A. Akimov, et al., Chemotherapy of Malignant Tumors
Petersburg • 1999
View 1 Excerpt

Structure and Control of Ovarian Function [in Russian

O. V. Volkova
Moscow • 1980
View 1 Excerpt

The Long-Term Effects of Medical Treatment with Chemical Substances

I. F. Sanotskii, V. N. Fomenko
[in Russian], • 1979
View 2 Excerpts

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