Morphological analysis of tumor cell/endothelial cell interactions under shear flow.

@article{ChotardGhodsnia2007MorphologicalAO,
  title={Morphological analysis of tumor cell/endothelial cell interactions under shear flow.},
  author={Roxana Chotard-Ghodsnia and Oualid Haddad and Anne A. Leyrat and Agnes Drochon and Claude Verdier and Alain Duperray},
  journal={Journal of biomechanics},
  year={2007},
  volume={40 2},
  pages={335-44}
}
In the process of hematogenous cancer metastasis, tumor cells (TCs) must shed into the blood stream, survive in the blood circulation, migrate through the vascular endothelium (extravasation) and proliferate in the target organs. However, the precise mechanisms by which TCs penetrate the endothelial cell (EC) junctions remain one of the least understood aspects of TC extravasation. This question has generally been addressed under static conditions, despite the important role of flow induced… CONTINUE READING
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Molecular basis of the effects of shear stress on vascular endothelial cells

  • Li, Y-S.J, J. H. Haga, S. Chien
  • J. Biomechanics
  • 2005
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