Morphological adaptations in breast cancer cells as a function of prolonged passaging on compliant substrates

@inproceedings{Syed2017MorphologicalAI,
  title={Morphological adaptations in breast cancer cells as a function of prolonged passaging on compliant substrates},
  author={Sana Syed and Joseph M Schober and Alexandra Blanco and Silviya Petrova Zustiak},
  booktitle={PloS one},
  year={2017}
}
Standard tissue culture practices involve propagating cells on tissue culture polystyrene (TCP) dishes, which are flat, 2-dimensional (2D) and orders of magnitude stiffer than most tissues in the body. Such simplified conditions lead to phenotypical cell changes and altered cell behaviors. Hence, much research has been focused on developing novel biomaterials and culture conditions that more closely emulate in vivo cell microenvironments. In particular, biomaterial stiffness has emerged as a… CONTINUE READING

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