Morphological Factor Estimation via High-Dimensional Reduction: Prediction of MCI Conversion to Probable AD

@inproceedings{Duchesne2011MorphologicalFE,
  title={Morphological Factor Estimation via High-Dimensional Reduction: Prediction of MCI Conversion to Probable AD},
  author={Simon Duchesne and Abderazzak Mouiha},
  booktitle={International journal of Alzheimer's disease},
  year={2011}
}
We propose a novel morphological factor estimate from structural MRI for disease state evaluation. We tested this methodology in the context of Alzheimer's disease (AD) with 349 subjects. The method consisted in (a) creating a reference MRI feature eigenspace using intensity and local volume change data from 149 healthy, young subjects; (b) projecting MRI data from 75 probable AD, 76 controls (CTRL), and 49 Mild Cognitive Impairment (MCI) in that space; (c) extracting high-dimensional… CONTINUE READING