Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene.

@article{Matolcsy1996MorphologicTO,
  title={Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene.},
  author={Andr{\'a}s Matolcsy and Paolo Casali and Roger A. Warnke and D M Knowles},
  journal={Blood},
  year={1996},
  volume={88 10},
  pages={3937-44}
}
Follicular lymphoma (FL) is a low-grade B-cell non-Hodgkin's lymphoma (NHL) that frequently transforms into diffuse aggressive NHL. The majority of FLs display a t(14; 18) translocation that places the bcl-2 gene into juxtaposition with the lg heavy-chain (H) gene locus. Morphologically transformed malignant FL cells retain their t(14;18) translocation and may acquire additional genetic abnormalities. We analyzed serial biopsy specimens from eight patients with FL for secondary alterations of… CONTINUE READING

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