Morphologic study of the participation of the complement system in hyperacute rejection of renal xenotransplants.

@article{MejaLaguna1972MorphologicSO,
  title={Morphologic study of the participation of the complement system in hyperacute rejection of renal xenotransplants.},
  author={J E Mejĩa-Laguna and Adolfo Mart{\'i}nez-Palomo and C. E. Biro and Bibiana Ch{\'a}vez and Fernando L{\'o}pez-Soriano and M Carcĩa-Cornejo},
  journal={The American journal of pathology},
  year={1972},
  volume={69 1},
  pages={71-8}
}
The role of polymorphonuclear leukocyte (PMN) and platelet infiltration in the hyperacute rejection of renal xenotransplants was studied. In a first group, a dog kidney was grafted to rabbit recipients with intact immune adherence and chemotaxis. A second group included recipients depleted of PMN's with nitrogen mustard, and in a third group, immune adherence and chemotaxis were modified by depleting the third component of complement by means of cobra venom factor. Serial kidney biopsies were… CONTINUE READING