Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis

  title={Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis},
  author={Jurgen Ludwig and Steven S. Barham and Nicholas F. LaRusso and Lila R. Elveback and Russell H. Wiesner and John T. McCall},
Histologic, ultrastructural, chemical, and statistical methods were used to study liver biopsy and autopsy specimens from 43 patients who had primary sclerosing cholangitis (PSC), with or without chronic ulcerative colitis (CUC), and from 19 patients who had CUC without PSC. In all study groups, essentially the same abnormalities were found in the hepatic parenchyma outside the major bile ducts, although nondiagnostic tissue samples were observed also. Specimens from patients with extrahepatic… Expand

Paper Mentions

Interventional Clinical Trial
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Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease of the liver and that is characterized by progressive inflammation, fibrosis, and stricturing of the intrahepatic andExpand
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Diagnosis of primary sclerosing cholangitis.
  • P. Harrison
  • Medicine
  • Journal of hepato-biliary-pancreatic surgery
  • 1999
The most characteristic histological feature of primary sclerosing cholangitis is periductal concentric obliterative fibrosis of small interlobular bile ducts with or without proliferation of bileducts in portal tracts, but liver biopsy findings alone are infrequently diagnostic. Expand
Precancerous Bile Duct Pathology in End-stage Primary Sclerosing Cholangitis, With and Without Cholangiocarcinoma
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Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis.
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Histological and ultrastructural examination of the intrahepatic biliary tree in primary sclerosing cholangitis.
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Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
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