Morphologic effects of artemisinin in Plasmodium falciparum.

  title={Morphologic effects of artemisinin in Plasmodium falciparum.},
  author={Yoshimasa Maeno and Takae Toyoshima and Hisashi Fujioka and Yoko Ito and Steven Richard Meshnick and Achille Benakis and Wilbur K. Milhous and Masamichi Aikawa},
  journal={The American journal of tropical medicine and hygiene},
  volume={49 4},
Ultrastructural changes induced in Plasmodium falciparum by artemisinin were studied in vitro. Electron microscopic autoradiography was performed on infected erythrocytes that were exposed in vitro to 3H-dihydroartemisinin and 14C-artemisinin. These drugs consistently were located in food vacuoles and mitochondria. Two hours after administration, changes were observed in parasite mitochondria, rough endoplasmic reticulum, and nuclear envelope. At four hours, in addition to the earlier changes… CONTINUE READING

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