Morphologic changes induced by neoadjuvant androgen ablation may result in underdetection of positive surgical margins and capsular involvement by prostatic adenocarcinoma.

Abstract

OBJECTIVE Neoadjuvant androgen ablation (NAAA) causes significant cytoarchitectural changes in both benign and malignant prostatic epithelial cells that may contribute to underdetection of prostate cancer capsular involvement and positive surgical margins. METHODS The aim of this study is to determine the ability of cytokeratin immunohistochemistry to… (More)

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@article{Bazinet1997MorphologicCI, title={Morphologic changes induced by neoadjuvant androgen ablation may result in underdetection of positive surgical margins and capsular involvement by prostatic adenocarcinoma.}, author={Michel Bazinet and Wei Zheng and Louis R{\'e}al B{\'e}gin and Armen G. Aprikian and P. I. Karakiewicz and M. M. Elhilali}, journal={Urology}, year={1997}, volume={49 5}, pages={721-5} }