Morphologic and immunohistochemical changes in prostate cancer after preoperative hormonal therapy. A comparative study of radical prostatectomies.

@article{Voorde1994MorphologicAI,
  title={Morphologic and immunohistochemical changes in prostate cancer after preoperative hormonal therapy. A comparative study of radical prostatectomies.},
  author={W M Van de Voorde and A A Elgamal and Heinrik van Poppel and Eric K. Verbeken and L. V. Baert and Joseph M. Lauweryns},
  journal={Cancer},
  year={1994},
  volume={74 12},
  pages={3164-75}
}
BACKGROUND Estramustine phosphate (EMP) and flutamide (FL) were used as reversible preoperative hormonal drugs in the surgical treatment of patients with localized prostate cancer. METHODS The authors descriptive and quantitatively examined the morphologic and immunohistochemical changes in 40 of 200 step-sectioned radical prostatectomies, obtained after treatment with EMP (25 patients) and with FL (15 patients). Of these, 28 pretreatment needlecore biopsies were available. RESULTS Every… CONTINUE READING