Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.

@article{SCHUMER1992MorphologicBA,
  title={Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.},
  author={Mr. SCHUMER and Marie Claude Colombel and Ihor S. Sawczuk and Glenda G Gobe and Jerome Connor and Kathleen O'toole and Carl A. Olsson and Gilbert J. Wise and Ralph Buttyan},
  journal={The American journal of pathology},
  year={1992},
  volume={140 4},
  pages={831-8}
}
A multiparametric analysis to demonstrate that even brief periods of arterial clamping can initiate extensive cell loss in a rat kidney through the process of apoptosis during the 48-hour period after reperfusion was performed. Microscopic examination of rat renal tissues subject to a 5-, 30-, or 45-minute period of complete ischemia showed the presence of apoptotic bodies both within and occasionally between renal tubules, appearing as early 12 hours after reperfusion, and increasing in… CONTINUE READING