• Corpus ID: 82545225

Morpholinophosphorodichloridate, a New Phosphorylating Agent directly forming Nucleoside Polyphosphate from Nucleosides

@article{1962MorpholinophosphorodichloridateAN,
  title={Morpholinophosphorodichloridate, a New Phosphorylating Agent directly forming Nucleoside Polyphosphate from Nucleosides},
  author={池原 森男 and 大塚 栄子},
  journal={Chemical \& Pharmaceutical Bulletin},
  year={1962},
  volume={10},
  pages={536-537}
}
4 Citations
The Facile Synthesis of 5′-Nucleotides by the Selective Phosphorylation of a Primary Hydroxyl Group of Nucleosides with Phosphoryl Chloride
5′-Nucleotides were directly prepared by selective phosphorylation with phosphoryl chloride in the presence of water and pyridine in acetonitrile. The rate of phosphorylation with phosphoryl chloride
Studies of phosphorylation. I. Phosphorylation of 2',3'-o-isopropylidene nucleoside by phosphoryl chloride.
TLDR
2′, 3′-O-Isopropylidene derivatives of adenosine, inosine, and guanosine gave the corresponding 5′-nucleotides in good yields, whereas that of xanthosine reacted very slowly, unlike the above nucleosides.