Morpholino antisense oligonucleotides: tools for investigating vertebrate development

@article{Corey2001MorpholinoAO,
  title={Morpholino antisense oligonucleotides: tools for investigating vertebrate development},
  author={David R. Corey and John M. Abrams},
  journal={Genome Biology},
  year={2001},
  volume={2},
  pages={reviews1015.1 - reviews1015.3}
}
Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential. 

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The type I serine / threonine kinase receptor Alk 8 / Lostafin is required for Bmp 2 b / 7 signal transduction during dorsoventral patterning of the zebrafish embryo

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