Morpholino antisense oligomers: design, preparation, and properties.

@article{Summerton1997MorpholinoAO,
  title={Morpholino antisense oligomers: design, preparation, and properties.},
  author={J. Summerton and D. Weller},
  journal={Antisense & nucleic acid drug development},
  year={1997},
  volume={7 3},
  pages={
          187-95
        }
}
  • J. Summerton, D. Weller
  • Published 1997
  • Chemistry, Medicine
  • Antisense & nucleic acid drug development
  • Antisense promised major advances in treating a broad range of intractable diseases, but in recent years progress has been stymied by technical problems, most notably inadequate specificity, ineffective delivery into the proper subcellular compartment, and unpredictable activity within cells. Herein is an overview of the design, preparation, and properties of Morpholino oligos, a novel antisense structural type that solves the sequence specificity problem and provides high and predictable… CONTINUE READING
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