Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB.

@article{Rolo2009MorphogeneticMD,
  title={Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB.},
  author={Ana Rolo and Paul Skoglund and Ray Keller},
  journal={Developmental biology},
  year={2009},
  volume={327 2},
  pages={
          327-38
        }
}
Vertebrate neural tube formation involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate driven largely by cellular apical constriction. However, the cellular and molecular biomechanics of these processes are not understood. Here, using tissue-targeting techniques, we show that the myosin IIB motor protein complex is essential for both these processes, as well as for conferring resistance to deformation to… CONTINUE READING

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